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PaulB Offline OP
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I don't know if anyone else seen this, but here is a report made earlier this month by Memorial Sloan Kettering Cancer Center in NYC, to the Journal of Clinical Oncology, questioning wether Erbitux shoould replace Cisplatin for chemoradiation in Locally Advanced Head and Neck Cancer, outside clinical trials, anytime soon, until further studies are done.

http://jco.ascopubs.org/content/early/2012/11/30/JCO.2012.46.9049


10/09 T1N2bM0 Tonsil
11/09 Taxo Cisp 5-FU, 6 Months Hosp
01/11 35 IMRT 70Gy 7 Wks
06/11 30 HBO
08/11 RND PNI
06/12 SND PNI LVI
08/12 RND Pec Flap IORT 12 Gy
10/12 25 IMRT 50Gy 6 Wks Taxo Erbitux
10/13 SND
10/13 TBO/Angiograph
10/13 RND Carotid Remove IORT 10Gy PNI
12/13 25 Protons 50Gy 6 Wks Carbo
11/14 All Teeth Extract 30 HBO
03/15 Sequestromy Buccal Flap ORN
09/16 Mandibulectomy Fib Flap Sternotomy
04/17 Regraft hypergranulation Donor Site
06/17 Heart Attack Stent
02/19 Finally Cancer Free Took 10 yrs






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Paul

Thank you for posting that. MSKCC is highly regarded by OCF posters. Erbitux has been a hot button issue here (okay, I get all hot about it and make it an issue). This study sums up the reasons why my RO at a CCC now refuses to give Erbitux and instead uses Carboplatin or Cisplatin: his patients who he had given Erbitux have had more recurrences than those he treated with platinum chemo. Ironically, I asked my RO to treat me with this "miracle drug" based on all the glowing articles overstating the Bonner results (which really only showed that Erbitux works better than nothing at all for chemo) as well as the newspaper articles at the time about "mean" countries denying state insurance coverage for Erbitux.
As the article notes, the Clinical trial comparing Erbitux to Cisplatin will finally answer these questions, although my guess is that the trial may be discontinued once the preliminary results are in.
I was glad to see the sentence with footnote 16 about the analysis of the Spectrum trials showing that Erbitux did not play well with HPV when used to treat recurrence or metastasis, When I first posted that possibility, I got lots of pushback so a MSKCC article helps validate my concern.
This is one time I hope I am wrong as many OCF posters have relied upon Erbitux. Plus it's important not to overstate Erbitux's limitations, it does work, but has not been proven to work better or even as well as cisplatin and carboplatin. That's the information I wish I had known back in 2007.
Charm
.


65 yr Old Frack
Stage IV BOT T3N2M0 HPV 16+
2007:72GY IMRT(40) 8 ERBITUX No PEG
2008:CANCER BACK Salvage Surgery
25GY-CyberKnife(5) 3 Carboplatin
Apaghia /G button
2012: CANCER BACK -left tonsilar fossa
40GY-CyberKnife(5) 3 Carboplatin

Passed away 4-29-13
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PaulB Offline OP
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I knew someone mentioned their doctor not wanting to prescribe Erbitux anymore, and possibility of a report coming out, and my reason for posting this. The report also mentions disappointing findings combining Erbitux with Cisplatin for chemoradiation in HPV. I just completed treatment last month with Erbitux, but also with Taxotere. I had Cisplatin before, and to harsh for my kidneys now.


10/09 T1N2bM0 Tonsil
11/09 Taxo Cisp 5-FU, 6 Months Hosp
01/11 35 IMRT 70Gy 7 Wks
06/11 30 HBO
08/11 RND PNI
06/12 SND PNI LVI
08/12 RND Pec Flap IORT 12 Gy
10/12 25 IMRT 50Gy 6 Wks Taxo Erbitux
10/13 SND
10/13 TBO/Angiograph
10/13 RND Carotid Remove IORT 10Gy PNI
12/13 25 Protons 50Gy 6 Wks Carbo
11/14 All Teeth Extract 30 HBO
03/15 Sequestromy Buccal Flap ORN
09/16 Mandibulectomy Fib Flap Sternotomy
04/17 Regraft hypergranulation Donor Site
06/17 Heart Attack Stent
02/19 Finally Cancer Free Took 10 yrs






Joined: Oct 2011
Posts: 805
KP5 Offline
"Above & Beyond" Member (500+ posts)
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I only hope that we stay away from recurrence since Kev had Erbitux only with his IMRT. He did have the induction chemo with Cistplatin, 5FU and Taxotere, so hopefully we'll be ok. I know there are no guarantees either way.
Kathy


Kathy wife/caregiver to:
Kevin age:53
Dx 7/15/11
HPV16+ SCC Stage IV BOT/R
Non smoker, casual drinker
7/27/11 Cistplatin, taxotere,5FU 2/3week sessions, followed by IMRT 125cgy x 60 (2x daily) w/Erbitux weekly. Last rad 10/26/11. Last Erbitux 10/27/11
PEG placed 9/1/11 Removed 11/8/11
Clear PET 10/12 and 10/13 and ct in 6/14
Joined: Jul 2012
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PaulB Offline OP
Patient Advocate (old timer, 2000 posts)
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Joined: Jul 2012
Posts: 3,267
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Kathy, I only had 5 days of induction chemo, with the same chemos, and it killed off everything, nearly me included lol, for 9 months, but Kevin is getting chemoradiation also, which is the key.


10/09 T1N2bM0 Tonsil
11/09 Taxo Cisp 5-FU, 6 Months Hosp
01/11 35 IMRT 70Gy 7 Wks
06/11 30 HBO
08/11 RND PNI
06/12 SND PNI LVI
08/12 RND Pec Flap IORT 12 Gy
10/12 25 IMRT 50Gy 6 Wks Taxo Erbitux
10/13 SND
10/13 TBO/Angiograph
10/13 RND Carotid Remove IORT 10Gy PNI
12/13 25 Protons 50Gy 6 Wks Carbo
11/14 All Teeth Extract 30 HBO
03/15 Sequestromy Buccal Flap ORN
09/16 Mandibulectomy Fib Flap Sternotomy
04/17 Regraft hypergranulation Donor Site
06/17 Heart Attack Stent
02/19 Finally Cancer Free Took 10 yrs







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