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"OCF Down Under"
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"OCF Down Under"
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Hi all,

As part of my wife's Tx, the doctor asked us whether or not she would be interested in taking 3 larger doses in week 1,4 & 7 of Cisplatin rather than 7 smaller doses each week.

He said that there was some evidence to suggest that by administering higher doses have shown to improve prognosis (although inconclusive) but it comes with more difficult side affects to deal with afterwards.

Any ideas / suggestions?

Thanks in advance.

Last edited by Jay Jeong; 09-28-2012 01:17 AM.

6/8/12: Wife 33y/o with no risk dx with Stage IVa SCC L of Tongue(T4aN2bM0)
3/9/12: Induced birth @ 36 weeks - Baby Hunter!
11/9/12: OP - 3/4 Partial Gloss, Radical ND & Tongue Rec.
24/10/12: 33xRad + 7xChemo
7/12/12: Tx complete
21/3/13 & 21/6/13: NED
24/7/13: SCC in Lungs - OP: Lobectomy (VATS)
29/1/14 passed away
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Patient Advocate (old timer, 2000 posts)
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Joined: Jul 2012
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I read similar, about the weekly smaller doses being less toxic, but also read that the weekly doses has more long term side effects, compared to the larger dosed standard 3 bag treatment. To what extent, I do not recall, and hope to come across it again. Good luck.


10/09 T1N2bM0 Tonsil
11/09 Taxo Cisp 5-FU, 6 Months Hosp
01/11 35 IMRT 70Gy 7 Wks
06/11 30 HBO
08/11 RND PNI
06/12 SND PNI LVI
08/12 RND Pec Flap IORT 12 Gy
10/12 25 IMRT 50Gy 6 Wks Taxo Erbitux
10/13 SND
10/13 TBO/Angiograph
10/13 RND Carotid Remove IORT 10Gy PNI
12/13 25 Protons 50Gy 6 Wks Carbo
11/14 All Teeth Extract 30 HBO
03/15 Sequestromy Buccal Flap ORN
09/16 Mandibulectomy Fib Flap Sternotomy
04/17 Regraft hypergranulation Donor Site
06/17 Heart Attack Stent
02/19 Finally Cancer Free Took 10 yrs






Joined: Sep 2006
Posts: 8,311
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Patient Advocate (old timer, 2000 posts)
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Patient Advocate (old timer, 2000 posts)

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Posts: 8,311
While I have never seen a study that compares the 3 Big Bag method to the Weekly approach we have had numerous posters tell us that their side effects were not as severe with the weekly vs what we all know from experience with the more standard Big Bag method. I also am not aware of any study that compares the effectiveness of one over the other. My only concern is that her cancer is HPV- and therefore is harder to kill and more likely to recur than HPV+ SCC so I would be more inclined to go with the standard 3 Bag method with the assumption (not medically based knownledge) that the worst for us is likewise for the cancer.


David

Age 58 at Dx, HPV16+ SCC, Stage IV BOT+2 nodes, non smoker, casual drinker, exercise nut, Cisplatin x 3 & concurrent IMRT x 35,(70 Gy), no surgery, no Peg, Tx at Moffitt over Aug 06. Jun 07, back to riding my bike 100 miles a wk. Now doing 12 Spin classes and 60 outdoor miles per wk. Nov 13 completed Hilly Century ride for Cancer, 104 miles, 1st Place in my age group. Apr 2014 & 15, Spun for 9 straight hrs to raise $$ for YMCA's Livestrong Program. Certified Spin Instructor Jun 2014.
Joined: Sep 2012
Posts: 145
"OCF Down Under"
Senior Member (100+ posts)
OP Offline
"OCF Down Under"
Senior Member (100+ posts)

Joined: Sep 2012
Posts: 145
Hi David,

Thanks for your advice.

It was quite amazing that none of the doctors here have actually checked for HPV16 despite numerous requests stating that the cancer is on the oral tongue, and the probability is very low that it would be HPV+

The pathology report after surgery has come out all clear but one of the frozen margin rates was only 2mm and hence they wanted to be safe and go ahead with chemo on top of the radiotherapy.

Will make sure to do a bit more digging up but it's a tough decision to make for my wife as she has gone through so much up till date..


6/8/12: Wife 33y/o with no risk dx with Stage IVa SCC L of Tongue(T4aN2bM0)
3/9/12: Induced birth @ 36 weeks - Baby Hunter!
11/9/12: OP - 3/4 Partial Gloss, Radical ND & Tongue Rec.
24/10/12: 33xRad + 7xChemo
7/12/12: Tx complete
21/3/13 & 21/6/13: NED
24/7/13: SCC in Lungs - OP: Lobectomy (VATS)
29/1/14 passed away

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