You could try gently plunging with warm water, if that not effective pineapple juice, cranberry juice or coca cola. As mentioned above thorough rinsing of the tube after each use is very important. It should also be rinsed a couple of times a day when not in use just to maintain patency. If all fails contact Dr. who put tube in, it is possible it could have kinked inside the gut. This happened to one of my husband's PEG tubes and it had to be replaced.