Hi Sandy,
Two reasons the doctors consider my husband's cancer very aggressive (we are on #4 since 2005) are that his is poorly differentiated, which means it grows very quickly. He also has PNI or Peri-neural invasion. I don't know what the percentages are of all SCC having these characteristics, but it would be interesting to find out.
Lori


Lori, cg to H Ron, age 56.
Stage IV Oral SCC-T1N2. Tongue resected and right ND 8/05. Teeth removed, PORT, PEG, IMRT x33, Cisplatin x3. Tx ended 10/05.
Recurrence 7/08 Stage IV. Surgery 8/30/08.
2nd recur. 11/08. 2nd surgery 2/2/09.
3rd recur. 4/9/09. Erbitux wkly. 5/09-?
Ron died 6/6/09.
Lori also passed away 8/20/11, colon cancer