Mike T.
Re my quote:
->> If you get a full blood transfusion you will automatically get also white blood cells (including granulocytes, macrophages etc) UNLESS the blood was processed by leukoreduction. The question then is this. Do you need fresh cells for this activity and how frequent is the super donor? My point is unless this is very rare or you actually need fresh cells (both are possibilities) it should have been detected since transfusions are not uncommon in cancer patients.
PS (if you read out of 500 volunteers 100 people will be asked to donate... that does not sound that rare to me)
EricS:
Is is not that simple.
First of all the article (above) was adapted from a PRESS RELEASE!! (=propaganda). This is hardly a place to get the real scoop. Also it is not clear what malignancies they talk about. The 2006 PNAS paper refers to just 3 mouse cancer cell lines.
Some mice are resistant to these cancer cell lines while "normal" mice are not.
You also should have a close look at their own web site
http://www1.wfubmc.edu/tumorbio/srmouse/part3.htmFirst of all these mice are twins, they are genetically identical except for SR/CR mutation ! Read the caveat after that statement.
Then also look at their figure 6. They inject the MUTANT mouse and the NORMAL mouse with an EXTERNAL cancer cell line. The normal mouse develops cancer the mutant does not. Then they harvest the leukocytes of the mutant mouse and inject that into the normal mouse.
The tumors cell lines used were identical and it is the experienced mutant leukocytes that did the killing. A key point is that these mice are twins, you could transplant legs etc between them without any rejection. Another point is that the tumors were externally introduced, this is not how we get it. We make them ourselves, unfortunately.
I find the idea extremely interesting but I also think that much more research is needed. There are a couple of strange things going on here.
A) why is there no update in the publications past 2006?
B) I could not find recent papers on the subject by the lead investigator.
C) His collaborator (head of unit) with whom he had several papers has an updated CV.... yet there is not a single publication past the 2006 PNAS paper with his collaborator?
D) dead links
M
