I participated in the same Clinical trial at MD Anderson. See my post regarding it here.
http://oralcancersupport.org/forums...t&Main=1118&Number=9607#Post9607I tested positive for the marker, and felt like the extra surveillance, and possible prevention from the chemo if I wasn't assigned the placebo, was worth it. I completed the active part of the study with no undue side effects in April and now am seen every 6 months by both the oncologist, who is the study chair, and also still with my surgeon.
More information can be found about the trial here:
http://clinicaltrials.gov/ct2/show/NCT00402779Please let me know if you have other questions.