Pam,

I wonder if you can split the dosage like I do. You might want to ask if you can.

I worked my way up to 10/wk. The first two weeks, I took 5/wk. Then, I added another one each week. My rheumatologist wanted to start out at the lowest dosage that reduced the R.A. inflammation.

Also, MTX can sometimes cause oral sores ... just what you need to hear, I'm sure. They are very, very, very small. Most sores will go away if you take extra folic acid. Mine disappeared about 3 days after I started taking extra folic acid.

You may have seen this already. The Arthritis Foundation website says that these are the most common side effects: Abdominal discomfort; chills; dizziness; fever; general feeling of illness; hair loss; headache; increased sun sensitivity; itching; liver problems; low blood counts; mouth sores; nausea and stomach upset; rashes; shortness of breath; yeast infection.

Nothing bothers me with it now. Hope it is smooth for you, too.

Jean