I was taking systemic and localized medications for fungus/yeast infections in my mouth. But, the white spots would not go away! One day I went to my main oncologist and he said that the white spots looked more like radiation changes. So, the next time I went to my RO, I asked him to do a culture of my throat. Sure enough, it came back negative for yeast/fungus! I was taking all those medications for nothing. Moral of the story,,,have a culture done to make sure you do indeed have the fungus. Good luck to you!