Deb, I didn't start feeling any side effects until around the beginning of week 3. I never did get sick but lost all my taste and all my energy, and a lot of hair. It seemed like it happened at once. I was able to continue working all through the tx but there were days I wondered. I am 3 months post tx and am still getting over the side effects. My advise is to take it one day at a time and if Bill gets through it with minimal side effectss then that is one more thing to be grateful about. Good luck, Bill