Hi Tom,
My tumor started shrinking pretty quickly also. When they did the mid treatment (3 week) CT scan it had completely dissappeared.

According to the manufacturer, Zofran works for 60% of the population group taking it. It worked ok for me for a while. It only has a maximum effectiveness of 3-5 days then you must shift to another anti-emetic. I think in my case the Cisplatin worked too well. They decided to drop the last treatment (I was originally scheduled for 3), so I only had 2 chemotherapy sessions. I had multiple problems with constipation (probably from all of the pain meds -and it causes nausea too), nausea from the chemo and mucositus -nothing out of the ordinary really -just the usual treatment misery!. Things started to get better when I got weaned off of the pain meds. I didn't have a PEG tube so I needed the pain meds to swallow so don't be too hasty to get off of them. Pain management is an important aspect of the healing process.

The second chemo treatment was much worse for me but everyone reacts differently so you may be much more tolerant than I was. I may have been suffering from radiation sickness by then also.

I had IMRT and it spared all but one salivary gland. It has been recovering steadily. It can take 18 months or more for the surviving glands to heal. If you are having XRT, you may never regain salivary function. The Amofostine can be a difficult treatment for some. Some can not tolerate it.