Let me contribute what I can here. My treatment included daily Amifostine, given IV over 5 minutes, within 30 minutes of my radiation treatment. Thus, I had 39 Amifostine administrations.

I noticed no ill effects from the Amifostine at the beginning, but later on (about treatment 25), I would experience nausea about an hour after the administration. It was funny, because it was almost like clockwork. Walking from my radiation treatment to my car, the nausea would hit at about the same spot in my walk. Nothing severe, and it passed quickly. I did use Compazine at home however, in combination with a stool softener to mitigate against the constipation side effects.

In terms of impact on treatment, I discussed it with an oncological pharmacist attached to our local cancer center. He said that they have used and studied Amifostine extensively, and have not seen any adverse impact upon tumor responsiveness in their facility, but have seen positive influence in terms of salivary production.

I know that my dry mouth is actually worse now (60 days post treatment) than it was during treatment. Of course, I am no longer getting Amifostine, and I stopped the Salagen at the end of treatment. I am going to ask the doctor about that tomorrow.