Hi Carol, chemo is cumulative so the answer is yes it will be as bad and it's good to be prepared for that. Jack had lots of nausea but no vomiting for the first 3 treatments of cisplatin. The 4th one was a killer and he had problems with vomiting and severe nausea for several weeks after it ended. He did get through it but it was hard.

The main thing that helped was taking the zofran that dissolved under his tongue twice a day, plus emend on the chemo days, plus compazine suppositories for breakthrough nausea in addition to staying well hydrated. We probably also threw in some Ativan.

I did IV hydration at home thru his port on the evenings he received his treatments. You can also do hydration thru the PEG tube by using a kangaroo gravity bag on a slow drip - that makes it easier to tolerate sometimes with nausea. Any way he can get 2-3 quarts of water in him will work. As Gary said replacing fluids that he throws up is key.

We were told that the main thing was for him to at least have 2 treatments of cisplatin and they made the decisions on the 3rd and 4th cycles based on his blood work and his overall condition. If they think he won't tolerate it they won't give it.

Regards JoAnne