My husband had profound nausea with amiphostine. Compazine didn't touch it, but the Zofran ODT did help (the "orally disintegrating tablets" really work fast). He was able to get through 3 weeks of the amiphostine tx, not the full 6 and much of what we read said many patients can't tolerate the full course. But some people tolerate it well and I hope you're one of them!

Good for you for having the zofran ready. If I recall, an oncology nurse friend told me there *are* newer antiemetics than Zofran (more commonly prescribed for chemotherapy)- but they're incredibly expensive - might have trouble with insurance coverage. We didn't try them.

Good luck!