Oh my yes! The last week of rad and the two or three weeks following are when the pain is at its worst. Nothing less then Fentanyl patches should be accepted. Ask for them specifically. The docs told me they had never seen worse burns than I had, but with the Fentanyl, I was completely comfortable. I love that stuff, but had no trouble leaving it behind when I was better. It is important to follow the directions to the letter, but the relief provided is just wonderful!