Well guys, I have certainly learned ALOT about fentanyl in a very short amount of time :rolleyes: Since John started on the 1st one on July 6th, he has gotten progressively incoherent, confused, irritable and in short -looney! This am., when he registered a 101.5 degree fever I yanked the patch off.[O.K. there is more to the story, but I won't bore you] His Chemo Doc was not in favor of the patch to begin with and when we got to his office this am, he was glad it was gone. I really questioned him about needing to reapply smaller doses to let John come down off of the 50 mcg slowly.[John got mad at me, says I was too pushy with the Doctor] He said the Hydrocodone John is taking would stop any withdrawal symptoms. If it does not, I am going to be as mad as the proverbial Wet Hen! I do hope this thread will be of benefit to others who need to use this drug. It works great for many people, but it just did not work for us. Amy