I had cisplatin and I reacted poorly to it but that does NOT mean that you will too. Some antiemetics work very well. Zofran is the antiemetic of choice in conjunction with cisplatin. It is only effective for 3-5 days then you must shift to other antiemetics. I used compazine suppositories when I was too sick to keep anything down so it's handy to have some of those in your drug kit. I would be very nervous if they are suggesting compazine as your primary antiemetic. Be sure to ask them for a heating pad for your arm where the IV is - it'll make it a whole lot more comfortable. My experience was that the nausea didn't occur until after the infusion. They recommended having a full stomach and provided snacks and juices. DRINK LOTS OF WATER! Cisplatin is toxic to liver and especially kidneys. Water is important to flush it out. If you are having any ringing or other unusual hearing issues call your oncologist immediately. They will hydrate you thoroughly before they start the cisplatin and afterwards as well. Start drinking the water once you get home. They recommend 2-3 liters (4-6 12oz bottles)/day.

There was an interesting article about cisplatin in CURE magazine http://www.curetoday.com/