First, every one here is basically right. Here is the bottom line after all these posts in my mind. BobbyB needs to know for certain what it is that he has. He doesn't get any help from a doctor that says, "It doesn't look like anything serious" That is utter BS. No doctor, no matter how much experience, can tell you from just looking that it is or is not malignant. The Cdx brush is not a definitive diagnosis. It finds tissue which if dysplastic or malignant must still be sent for a real (not brush cytology) biopsy. It is primarily designed for dentists who see 3-5 abnormalities in the mouth every week, and rather than wait and watch, they want to know if it is really worth sending out for a punch or incisional biopsy. The light does even less. It only finds ANY suspect tissue, you bite your cheek, it finds it.... so I do not recommend that that be used as a DIAGNOSTIC tool, it is only a DISCOVERY tool, and we have already discovered that there is something here. So BobbyB, if he wants an answer and peace of mind, needs to quit pussy-footing around with this thing, especially given a tobacco history, and go to someone, ENT, oral surgeon, etc. and get a biopsy which is painless, cheap, and puts the matter to rest. There is nothing to debate here. If his ENT doesn't want to do it, go somewhere else. A biopsy ain't no big deal, and will take less than 5 minutes. In less than a week the answer will be there. An answer that is not ambiguous, and which will also define exactly if it is not malignancy, what it is