Dear Anne Marie, As CG to my 41 year old daughter with SCC lateral tongue (surgery 10/16, mod rad neck dissection, 1 positive lymph) and had her 10th IMRT treatment today I can completely empathize. She has Amaphostine before ea tx and gets horribly nauseated, in fact she's still throwing up at 6pm tonight. She's on Kytril, Ativan, Marinol & she still vomits in the car on the way home plus throughout the day. They're going to change her to Anzemet (from Kytril) on Monday along with the other 2 meds plus one of those seasick patches that you put behind the ear when you go on a cruise. If this last cocktail doesn't work the med oncologist is considering discontinuing the amaphostine altogether due to the strain on her overall health. As others on this board had noted amaphostine is REALLY hard to deal with because of the severe nausea and only a selected few make it through the entire regimine. My daughter is now entering the mouth pain stage (all her taste is gone) and she can barely swallow so this miserable vomiting and nausea all day long is a drug side effect she may no longer be able to tolerate. By the way, my daughter also has thrown a few tissy fits at me, but I chalk it up to how awful she's feeling & try not to take it personally (it's hard!). And I keep meticulous notes as to what goes in and what comes out - the doctors thank me for it! Hang in there = I'm right there with you! Bonnie "Worried Mom"