You have not said what it was that the doctors took out. Besides malignant masses, there are a variety of benign masses or lumps which may have been removed from your friends mouth. Cancers spread or metastasize when malignant cells travel through either the circulatory system with the blood or through the lymphatic system to distant locations from the original site of the primary cancer. The locations where you have described new lumps occuring, are certainly locations of groups of lymph nodes, and these are common sites for a metastasis to occur. I think that he should see a doctor to have these lumps examined and biopsied to know for sure what is happening. Most likely they will do a fine needle biopsy of several of the lumps, which is not that uncomfortable to have done, and not expensive. The small amount of cells removed by the needle will then be examinined by a pathologist. My personal preference would be to go to an oncologist who is familar with cancers rather than a general MD or general surgeon. If there is a cancer center or clinic close by, they will have a multidiciplinary staff who will be able to provide the most well rounded opinion. Remember that will all types of cancer, the best end results come from the earliest diagnosis and treatment. Please do not waste time looking for answers on the web.......only a trained professional can make a proper diagnosis after seeing the patient in person, and even then, only with a biopsy of the suspect tissue.