Al,

I didn't have either Amifostine or IMRT (they weren't available when I was treated 17 years ago), so I had conventional radiation and had major dry mouth problems afterward.

I've been using Salagen regularly (5mg 3x daily) for about 15+ years. In the early stages I had a "saliva surge" like Carol described and then it would wear off for awhile until the next dose. After some trial and error I found that it was somewhat better if I took it at the end of a meal (rather than on an empty stomach) -- that seemed to spread the effects a bit more over time. As more time has passed since my treatment, I've added the Biotene mouthwash/gel/spray products to my routine, and my salivary function has come back more than I expected, given that I didn't have any of the preventive measures that tend to be used now.

I know the healing process can be slow and frustrating, but hang in there -- it does get better.

Cathy