Sorry for your troubles BrandonK. This has happened to me several times. I'm surprised they didn't suggest radiation also, but your prior radiation, less than a year, may factor in. I would say the targeted therapy/chemo combination is better than nothing, but I would seek alternatives, having choices are always good, and select the most extensive treatment anyone can offer due to your history, negative prognoses, like ECE, lower nodal involvement, if it can be done safely, and maybe a 2nd opinion, preferably at a top CCC.

Good Iuck.