It takes almost 7-10 days for the nystatin to really knock thrush that's why the scrip is 14 days... You will get a lot if relief in the first 2-3 though. I'm not sure on the manuka helping this aspect of your journey... You really want to cut down on sugars as yeast thrives on it. Unpasteurized yogurt is great, the baking soda and salt swish, and I also used a 1:10 ratio of hydrogen peroxide to water mix to swish/ and brush my tongue with, definitely don't swallow it tho.