TPF Induction chemo is controversial, and many do not go on to complete the full induction chemo cycles, and or Chemoradiation or is delayed due to its high toxicities, including mortalities, but is very effective in killing cancer. One study said as high as 50% did not complete it. I had TPF,and ony did 5 days of TPF IC, which put me in a hospital, and acute critcal care nursing home for 187 days, paralyzed me from the waist down, lost over 110lbs in a few weeks, blinded me, and had 3rd degree burns to the hands, face, inside mouth, esophagus, feet, from Steven Johnson Syndrome, and much more. My local doctors said I was given too much chemo. and many doctors who came to see me for my care, including the burn unit who had to debrige the wounds, and couldn't believe chemo did that. As a result, I was unable to continue further treatment for over a year, and as a result of that, I have had numerous recurrences (8), and still have side effects, 4 years later, which were much worse than radiation. If TPF does kill all the cancer, which it can, it is short term only, and is likely to return within a year, if no further curative treatment is not done, and that is surgery, radiation, Chemoradiation. Carboplatin is an alternate to Cisplatin, with less side effects. Mine returned 8 months later, and then had radiation alone, and so on.

God luck to your son.