I had TPF alone, and is usually done in three cycles three weeks apart, as neoadjunt therapy before Chemoradiation. I could only do one week, and was hospitalized for 187 days. Sounds like an exception, but in one study 50% of patients are unable to complete the remainder of treatment or continue curative treatment because of the toxicities with this, which is either surgery, radiation or chemoradiation, and why it was and still is controversial, but it works. Chemo alone does not cure this cancer, it acts as a radiosensitizer, and can shrink tumors, although this induction chemo can eradicate all cancer, it does not last, and cancer usually returns in less than a year, mine did at 8 months.

The week dosage is usually 160mg Taxotere, 160mg Cisplatin and 1600mg 5-FU.

If other treatments, as mentioned, are done, it can be curative. If Chemo, like TPF Induction chemo, is used alone, probably not.