I have severe neuropathy for almost 4 years now from chemo, 24/7, in the hands, legs, causing muscle paralysis. It got somewhat better, but still can't feel or move my feet or move my toes. Nothing has helped. Most clears up in time, a few months, but in some cases can last as long as 17 years, and depends on the type of chemo, the amount, infusion rate, duration, and any underlying medical issues that can contribute to neuropathy.