Brian explains it better than anyone. Here is something I posted on another post, but think it's appropriate here. It may veer off the current discussion, but is HPV related. I have read, HPV outside the oropharynx, like oral tongue, elsewhere, do not have the same treatment response that we've seen in the tonsils, BOT to date. Just mentioning since there is talk with deescalation of treatment with HPV-positive in the Oropharynx, which should only be used in clinical trials, for now, but has anyone heard this, reason? I would think that Tobacco may be a factor. Is there talk of deesculation in areas outside the oropharynx for HPV-16 postive patients.

10/09 T1N2bM0 Tonsil
11/09 Taxo Cisp 5-FU, 6 Months Hosp
01/11 35 IMRT 70Gy 7 Wks
06/11 30 HBO
08/11 RND PNI
06/12 SND PNI LVI
08/12 RND Pec Flap IORT 12 Gy
10/12 25 IMRT 50Gy 6 Wks Taxo Erbitux
10/13 SND
10/13 TBO/Angiograph
10/13 RND Carotid Remove IORT 10Gy PNI
12/13 25 Protons 50Gy 6 Wks Carbo
11/14 All Teeth Extract 30 HBO
03/15 Sequestromy Buccal Flap ORN
09/16 Mandibulectomy Fib Flap Sternotomy
04/17 Regraft hypergranulation Donor Site
06/17 Heart Attack Stent
02/19 Finally Cancer Free Took 10 yrs