My husband was treated with the Cetuximab. He had the first-cycle rash (with is associated with its efficacy). We kept the rash under control with Aquaphor ointment. He was able to work for all but a couple of weeks of therapy, and has recovered very well. Charm's concerns with Cetuximab were personal (his first recurrence was after Cetuximab) and also based on comments from his doctors on their experience, not on a statistically rigorous trial. The RTOG 1016 study (which it sounds like you are in) is powered answer these questions.

It is my belief that my husband's doctors did not want to subject a scientist to a neurotoxic poison when there was a valid alternative - and it has worked out well thus far - knock wood!
Maria