I know HPV is not commonly associated with oral tongue cancers but does still factor in. Here's a study where 36% of oral tongue cancer cases were HPV+:

http://www.ncbi.nlm.nih.gov/pubmed/20413270

My husband was a patient through the VA and was biopsied and diagnosed at the VA. They did not test for HPV. His tumor started back of center and grew forward. He would have lost 75% of his tongue based on being seen right after diagnosis, but the tumor grew significantly in the six weeks until his scheduled surgery date and he probably would have faced a total glossectomy. The VA would not consider neoadjuvant treatment prior to surgery (the ENT said it does not result in less radical surgery) or chemoradiation as primary nor was he pointed to a clinical trial. So we looked elsewhere.


Wife/caregiver to David, age 54
Dx SCC of tongue 9/28/12, stage T4aN1M0
Tx cisplatin weekly x5 beg 11/21/12 tomotherapy radiation x35 beg 11/29/12, end chemo 12/24/12, end rad. 1/18/13
3/1/13 PET and CT NED
Adjunctive carbotplatin + taxotere x3 June/July 2013
Dx recurrence 6/8/2017
Tx Keytruda July 2017 - Feb 2018
Total glossectomy w/thigh free flap + selective neck dissection 4/12/18
quit smoking 31 yrs ago