Hi Ray! Hope you are well. Glad your BIL sought you out and you have pointed his friend in the right direction.
My concern would be where he is being treated. A CCC would be the best place to go. In TX, MDA is the best one to check out.
There are many members who are non
HPV and also non smokers. They have no known cause. Your BIL's friend may fall into that category.
Hope he will contact you and check out the forum. Im sure you can give him a hand and I know we can too.