There is much we know about these herbals and much that we do not. The thing that bothers me the most is that there is no regulation of them by anyone. Echinacea from one manufacturer may not be anything like the same-labeled product from another for instance. There are also no controls that are enforceable to ensure that they are free of contaminants, as the manufacturers are unregulated. In all this there is also a ton of misinformation from a variety of sources, because there have been few controlled studies of herbals. As in all things, make sure you have the best possible information from the best possible sources. Please read new article we are putting up tomorrow on dangerous herbals from the Consumers Union and the FDA.