Erbitux is a thorny question. Klo is correct that the citations and reports I have posted do not resolve this issue. I hope that the new clinical trial mentioned in other threads will provide clearer answers. It's comforting that Dr. Gillison and OCF are involved in that trial.
Bear in mind, that I actually had Erbitux so it's not academic to me but personally evidentiary. I'm puzzled by any assertion that using a targeted therapy like Erbitux whose sole anti cancer action is blocking EGFR would somehow be effective in situations where the tumor does not express much EGFR and have not heard nor read of any doctor or medical facility as thinking so. To me, that is illogical
The shocking failure of Erbitux in a large percentage of colon cancer patients after being touted as a miracle drug there is also a cause of concern.
Last but hardly least for patients, the carboplatin side effects were a walk in the park compared to Erbitux.

I also note most of the comments about how less toxic and easy Erbitux is or that it even works, have not come from patients who actually had Erbitux. It is an assertion by its manufacturer so IMO, Erbitux is a gamble since there is no doubt that the platinum based drugs work on everyone despite their genetic makeup or EGFR expression.

Again, I admit my bias against Erbitux. I wish wholeheartedly that my misguided faith in Erbitux had been undermined by critical comments like I have posted. My MO was and is a wonderfully compassionate doctor who cared about me as a person and patient and truly thought, based on the hype of Erbitux, that it would be the best for me. His and my "Blind acceptance" of Erbitux's purported efficacy did not pan out well. Plus I was exceptionally healthy and had great creatine levels, I am so glad and thankful that my MO reviewed all the studies again but gave precedence to the evidence before his eyes and urged me to use carboplatin after my cancer bounced back from it's Erbitux.
If he had been stubborn and just stuck to the Erbitux bandwagon, it would have made my choices far more difficult.
So far, the tried and true platinum chemo seems to have worked for me
Charm