Gary,
Your pdf on the complexities of RT is too heavy for me to read this afternoon, or perhaps I am just getting lazy, certainly impatient. You are obviously a smart guy so I will just take your word on it. The study you read about (breast cancer) I believe included H & N in phase II and earlier, with improvements noted there as well, but perhaps they thought there were more dramatic results for breast cancer so limited the finale to those patients. I just read they noted improvements in the neck structures in prior studies.
It seems to me there is little time spent on researching this issue. I did have this article bookmarked which is a fairly good summary on the topic:
http://jpkc.fimmu.com/fszlx/3-6/13Late%20radiation-related%20fibrosis%20pathogenesis,%20manifestations%20and%20current%20management.pdf
It includes head and neck. It is dated 2003, which doesn't make it cutting edge, but again, not much time is spent on this issue.
I had seen the medscape article.
Best,
Anne
SCC tongue 9/2010, excised w/clear margins:8 X 4 mm, 1 mm deep
Neck Met, 10/2010, 1 cm lymph node; 12/21/'10: Neck Diss 30 nodes, 29 clear, micro ECE node, part tongue gloss, no residual scc
IMRT & 6 cisplatin 1/20/11-2/28/11 at MDA
GIST tumor sarcoma, removed 9/2011, no chemo needed
Clear on both counts as of Fall, 2021
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