Bonnie,

This is called TIC regimen (Taxane, Ifosfamide and Carboplatin), old but yes has been superior in recurrent setting with improved outcomes and acceptable toxicity. Given in 3 days and repeated on day 21, with response assessed by CT/MRI after second cycle.

Broad spectrum antibiotics will take care of infection. Neulasta will revert the levels much before the next cycle.

Just take good care of John after 7-14 days following the chemo that is when his blood levels will be absolutely low.

My dad went through 3 cycles of DCF regimen much similar TIC and I was also worried about infection but he went through without much problems (except for mouth sores because of which he could not eat much). He also complained about nausea and stomach acidity.

My dad had Pegex (same as Neulasta) and yes it does cause bone pain.

So do talk to your MO about side effects. All the best to John and you - hoping for a positive news after his second cycle.