Hi Bonnie, hope you have explored other options like Taxane + Carboplatin + Fluorouracil. John might have already received Cisplatin with IMRT hence his MO is exploring other options including clinical trial.

While your MO is the best judge, Clinical Trial should be always last option in my opinion. And, even if it is a clinical trial, ask which phase it is in and how have been results of previous phases.

If you intend to go with clinical trial, do check for Reolysin with Paclitaxel and Carboplatin.

My prayers are with you and John. May god give you right directions.