My father has been diagnosed with recurrent nodal metastasis and he already had 3 x Chemo DCF (or TPF) regimen - Cisplatin (D1-D2: 60+60mg), Taxuba (D1: 120 mg), 5-FU (D1-D3: 1200mg).

He has also undergone RT RND + PMMC. Biopsy says SCC - 6 cm Nodal mass, Perineural Invasion (PNI), Extracapular extension (ECE), 3/10 Nodes, Soft tissue from carotid sheath and prevertebral muscles shows tumor deposits.

ENT will plan treatment this week and revert on 26th. Just wondering what could be a possible course of treatment.

DCF regimen did not help decreasing tumour size, probably malignant cells seems to have developed Cisplatin resistance due to his prior CRT in 2009.

Will RT alone help? Not too confident about Erbitux for concurrent CRT.


Father; 67 yrs; RIP: 2012/05/26

TX:SCC pT2N1M0G2;Glossectomy+SND+CCRT(59.3Gy+6xCis.)[2009]
TX:Nodal Mets; 3xDCF[2011/05/05]
TX: RND + PMMC Flap[2011/07/11]
DX:SCC PNI+ECE
TX:Re-RT 60Gy[2011/09/21]
TX:Gefitinib 250mg[2011/12/18]