While I did not have IORT (radiation during the operation), I did have a second course of radiation in to the same area and same tumor that I had a full course of 72GY on the first time.
My CCC however did not use IMRT the second time around, but instead used Cyberknife which is much more focused. That way they could pump another 25GY into me.
Bottom line: despite a very poor pathology report showing Perineural invasion and a tumor that proved resistant to Erbitux and radiation, the second round of radiation appears to have done the trick. Yes, there are some side effects, but one of them is being alive. So the second round worked for me and I hope it works for your wife also.
One thing I learned: be very sure to get your wife a TSH level blood test NOW. It is the only way to know if the second round of radiation causes thryoid damage since the lab ranges cannot establish what her true baseline should be. I do need to take thyroid medicine now but that's working well also
Charm