David

I did a personal experiment in this after reading a Yahoo article about a 2007 study. Bottom line, after three months of taking my thyroid medication before bedtime, my TSH level got even better as proven by my blood tests, than when I was taking the same dose in the morning. I was getting tired of getting up early to take Levoxyl so I could share my "breakfast" (coffee and 2 cans of Jevity 1.5) with my wife at our usual time together.

I discussed this very issue with my endocrinologist. As usual, I cross examined her on the basis for her recommendation that I take my levoxyl in the morning. She readily admitted it was what she was taught in medical school and that these were the instructions from the FDA insert. She had no independent basis and just had not questioned it. So I am not surprised that all the posters' doctors told them to take it in the morning. I like to know why my doctor thinks something and feel better when it's as a result of having done an operation or seen it in patients rather than hearing it in a lecture.

This last visit she agreed that while my TSH levels had been good and stable with morning dose, they were even better after I switched to evening.
Here is the link to Yahoo Should You Take Your Thyroid Medication at Night?

Last but not least, I found an article that in getting FDA approval, the hormone tests showed that some people, a very small percentage but statistically significant, found that taking their thyroid medication at night caused sleep problems. My understanding is that's the one and only documented reason for the generic recommendation to take thyroid medication in the morning. That way there is no requirement to list insomnia as a possible side effect.
Also the "take lots of water" thing was just because some people choked on the little pill, nothing else.

Thanks for posting about this study. It has really been nice to just wake up and eat breakfast (plus have coffee)
Charm