My RO prescribed trental for me about 6 months after RT. He had me take it with vitamin E (800 IU twice daily). He said I had the worst reaction to RT he has seen with mouth ulcers, swelling and my healing time was off the charts. I also showed signs of ORN as my front teeth started to loosen. He had me on the trental/vitamin E treatment for about 1-1/2 years. Eventually my team of doctors convinced me to give HBOT a try, so I went for 45 treatments. I would say the trental did help me, but it was a slow process. The HBOT had a quicker impact, but spending a few hours per day in the HBO chamber is like Marcus said a �major pain�. I have not had any dental work, so I cannot give you any input from that perspective.