I concur, but this is all that I came across. A study with a more comparable population (eating, drinking, smoking, health care etc) would be better. What is needed is an "identical" set of patients for the 3 vs 7 treatments.

.... It would seem reasonable that the younger group can tolerate a harsher treatment better than the older group. If the outcome and adverse effects are similar then this favors the weekly regimen (in my mind).

Perhaps we are splitting hairs here. The important thing may just be that one HAS concurrent chemo with IMRT. I will see my MO (young guy) this Saturday and will query him regarding and his take on this.

This one deals with recurrent HNC
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2621229
They strongly advocate radiation +/- chemo to reduce rHNC.

M




Partial glossectomy (25%) anterior tongue. 4/6/07/. IMRT start @5/24/07 (3x) Erbitux start/end@ 5/24/07. IMRT wider field (30x) start 6/5/07. Weekly cisplatin (2x30mg/m2), then weekly carbo- (5x180mg/m2). End of Tx 19 July 07.