Just to add, Induction chemo, IC, had been around for 40 years, and was originally used as organ preservation for Larynx cancers, possibly with just PF originally, and Taxotere was added, hence TPF, which was found to be safer, more effective than PF, from a Veterans Administration trial, with chemoradiation to follow. This was then used in pharynx cancers such as the oropharyngeal in BOT, Tonsil, with good results since the alternative was major surgery. From that, led to show good results with HPV oropharyngeal cancer also, which started to be shown as an increase cause of these type cancers, but HPV probably would have responded well to any type chemoradiation. As mentioned, IC is controversial, but several top CCC use it, but had no overall survival benefits shown through several studies, but local regional control, distant metastases were.

Here is a good article on IC, but may have have to sign in. There are many more trials, namely Decide, Paradigm, as well as articles, abstracts, many which I have since I have a personal interest in TPF IC.

http://jco.ascopubs.org/content/32/25/2685