#9268 01-21-2007 02:39 AM | Joined: Jul 2005 Posts: 624 "Above & Beyond" Member (500+ posts) | OP  "Above & Beyond" Member (500+ posts)
Joined: Jul 2005 Posts: 624 | I read this announcement in the Johns Hopkins Kimmel Cancer Center "Kimmel Wire", an email newsletter that comes out several times a year. Seems as if Viagra and related drugs can have anti-cancer properties, as they increase the ability of the immune system's T-cells to locate and kill cancer cells. Of course, for men there is that "side effect" to deal with!  Note that at least in vitro (tissue studies) this worked with head and neck cancer as well as other types. ""ERECTILE DYSFUNCTION" DRUGS HEIGHTEN NATURAL ANTI-CANCER ACTIVITY Sildenafil and other "impotence drugs" that boost the production of a gassy chemical messenger to dilate blood vessels and produce an erection now also show promise in unmasking cancer cells so that the immune system can recognize and attack them, say scientists at the Johns Hopkins Kimmel Cancer Center. Tests at Hopkins on mice with implanted colon and breast tumors showed that tumor size decreased two- and threefold in sildenafil-treated animals, compared to mice that did not get the drug. In mice engineered to lack an immune system, tumors were unaffected, proof of principle, the scientists say, that the drug is abetting the immune system
CG to husband Barry, dx. 7/21/05, age 66, SCC rgt. tonsil, BOT, 2 nodes (stg. IV), HPV+, tonsillectomy, 7x carboplatin, 35x tomoTherapy IMRT w/ Ethyol @ Johns Hopkins, thru treatment 9/28/05, HPV vaccine trial 12/06-present. Looking good!
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#9269 01-22-2007 04:06 AM | Joined: Sep 2006 Posts: 8,311 Senior Patient Advocate Patient Advocate (old timer, 2000 posts) | | Senior Patient Advocate Patient Advocate (old timer, 2000 posts)
Joined: Sep 2006 Posts: 8,311 | Gail,
My wife will not be happy when I show her this. She kiddingly (?) told our ENT friend that she would run him down in her car if he did anything to increase my sex drive when I was being radiated. LOL
David
Age 58 at Dx, HPV16+ SCC, Stage IV BOT+2 nodes, non smoker, casual drinker, exercise nut, Cisplatin x 3 & concurrent IMRT x 35,(70 Gy), no surgery, no Peg, Tx at Moffitt over Aug 06. Jun 07, back to riding my bike 100 miles a wk. Now doing 12 Spin classes and 60 outdoor miles per wk. Nov 13 completed Hilly Century ride for Cancer, 104 miles, 1st Place in my age group. Apr 2014 & 15, Spun for 9 straight hrs to raise $$ for YMCA's Livestrong Program. Certified Spin Instructor Jun 2014.
| | | | | Joined: Apr 2011 Posts: 3 Member | | Member
Joined: Apr 2011 Posts: 3 | [quote=Gail Mac]I read this announcement in the Johns Hopkins Kimmel Cancer Center "Kimmel Wire", an email newsletter that comes out several times a year. Seems as if Viagra and related drugs can have anti-cancer properties, as they increase the ability of the immune system's T-cells to locate and kill cancer cells. Of course, for men there is that "side effect" to deal with! Note that at least in vitro (tissue studies) this worked with head and neck cancer as well as other types. ""ERECTILE DYSFUNCTION" DRUGS HEIGHTEN NATURAL ANTI-CANCER ACTIVITY Sildenafil and other "impotence drugs" that boost the production of a gassy chemical messenger to dilate blood vessels and produce an erection now also show promise in unmasking cancer cells so that the immune system can recognize and attack them, say scientists at the Johns Hopkins Kimmel Cancer Center. Tests at Hopkins on mice with implanted colon and breast tumors showed that tumor size decreased two- and threefold in sildenafil-treated animals, compared to mice that did not get the drug. In mice engineered to lack an immune system, tumors were unaffected, proof of principle, the scientists say, that the drug is abetting the immune system [/quote] Thanks for sharing this important Post. On generic Viagra Vs Cancer | | | | | Joined: Nov 2006 Posts: 2,671 Patient Advocate (old timer, 2000 posts) | | Patient Advocate (old timer, 2000 posts)
Joined: Nov 2006 Posts: 2,671 | Anything that promises to kill cancer cells, increase libido and even size of one's instrument is very suspect in my opinion - especially when there is a link to buying the product touted. Also, in the phrase - "Note that at least in vitro (tissue studies) this worked with head and neck cancer as well as other types" it appears that it has only been observed in vitro which seems to indicate it has not been tested in human trials. Before rushing out to buy Viagra for my Smoker Son in the hopes of killing any cancer cells he might be harboring in his body -I am going to wait for some more definitive study. JMO
Anne-Marie
CG to son, Paul (age 33, non-smoker) SCC Stage 2, Surgery 9/21/06, 1/6 tongue Rt.side removed, +48 lymph nodes neck. IMRTx28 completed 12/19/06. CT scan 7/8/10 Cancer-free! ("spot" on lung from scar tissue related to Pneumonia.)
| | | | | Joined: Mar 2008 Posts: 3,082 Patient Advocate (old timer, 2000 posts) | | Patient Advocate (old timer, 2000 posts)
Joined: Mar 2008 Posts: 3,082 | I;m BACK early since I had to point out this was first announced in 2006 - FIVE YEARS AGO - Read it at the official John Hopkins site and OLD OLD news from John Hopkins
Last edited by Charm2017; 04-05-2011 05:34 PM.
65 yr Old Frack
Stage IV BOT T3N2M0 HPV 16+
2007:72GY IMRT(40) 8 ERBITUX No PEG
2008:CANCER BACK Salvage Surgery
25GY-CyberKnife(5) 3 Carboplatin
Apaghia /G button
2012: CANCER BACK -left tonsilar fossa
40GY-CyberKnife(5) 3 Carboplatin
Passed away 4-29-13
| | | | | Joined: Mar 2008 Posts: 3,082 Patient Advocate (old timer, 2000 posts) | | Patient Advocate (old timer, 2000 posts)
Joined: Mar 2008 Posts: 3,082 | The obvious question is why has there not been any announcements in the last five years that this really works. Nothing comes up on the John Hopkins web site since 2006 yet the article says they are testing it. Hmm, maybe these doctors have wives like David CPA - a new conspiracy theory. Or maybe it just did not stand up (bad pun) when tested Just teasing. Turns out Viagra does NOT WORK, - too short (no comments) a half life, but maybe Cialis - ah. the bathtub Heres the 2009 update from John Hopkins 2009 bathtubs for cancer
Last edited by Charm2017; 04-05-2011 05:53 PM. Reason: humor
65 yr Old Frack
Stage IV BOT T3N2M0 HPV 16+
2007:72GY IMRT(40) 8 ERBITUX No PEG
2008:CANCER BACK Salvage Surgery
25GY-CyberKnife(5) 3 Carboplatin
Apaghia /G button
2012: CANCER BACK -left tonsilar fossa
40GY-CyberKnife(5) 3 Carboplatin
Passed away 4-29-13
| | | | | Joined: Mar 2011 Posts: 131 Likes: 5 Senior Member (100+ posts) | | Senior Member (100+ posts)
Joined: Mar 2011 Posts: 131 Likes: 5 |
Lump in left side neck discovered Sept 2009
Misdiagnosed & FNA inconclusive
Large lymph node removed Nov. 2010 SCC and HPV16 pos
PET pointed tonsilectomy Feb. 2011
1ml tumor left side tonsil
Rads scheduled March 14th 2011. 2X36 GY's (72)
CarboTaxol once a week X 4 or 5 starting 4/5/11
No PEG
| | | | | Joined: Nov 2006 Posts: 2,671 Patient Advocate (old timer, 2000 posts) | | Patient Advocate (old timer, 2000 posts)
Joined: Nov 2006 Posts: 2,671 | MaineWill: I'm happy for you.
Anne-Marie
CG to son, Paul (age 33, non-smoker) SCC Stage 2, Surgery 9/21/06, 1/6 tongue Rt.side removed, +48 lymph nodes neck. IMRTx28 completed 12/19/06. CT scan 7/8/10 Cancer-free! ("spot" on lung from scar tissue related to Pneumonia.)
| | | | | Joined: Sep 2006 Posts: 1,357 Likes: 5 "OCF Canuck" Patient Advocate (1000+ posts) | | "OCF Canuck" Patient Advocate (1000+ posts)
Joined: Sep 2006 Posts: 1,357 Likes: 5 | You're brave Anne-Marie - I wasn't going to touch Maxine's line!!!
Too funny
Donna,69, SCC L Tongue T2N1MO Stg IV 4/04 w/partial gloss;32 radtx; T2N2M0 Stg IV; R tongue-2nd partial gloss w/graft 10/07; 30 radtx/2 cispl 2/08. 3rd Oral Cancer surgery 1/22 - Stage 1. 2022 surgery eliminated swallowing and bottom left jaw. Now a “Tubie for Life”.no food envy - Thank God! Surviving isn't easy!!!! .Proudly Canadian - YES, UNIVERSAL HEALTH CARE IS WONDERFUL! (Not perfect but definitely WONDERFUL)
| | | | | Joined: Nov 2006 Posts: 2,671 Patient Advocate (old timer, 2000 posts) | | Patient Advocate (old timer, 2000 posts)
Joined: Nov 2006 Posts: 2,671 | THe older you get, the braver you get. At least that's what happened to me. Took a while, tho'. 
Anne-Marie
CG to son, Paul (age 33, non-smoker) SCC Stage 2, Surgery 9/21/06, 1/6 tongue Rt.side removed, +48 lymph nodes neck. IMRTx28 completed 12/19/06. CT scan 7/8/10 Cancer-free! ("spot" on lung from scar tissue related to Pneumonia.)
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