Gretchen, how wonderful it is that he has a guardian angel like you along. A lot of the ROs will let you know "it's going to be a rough road" without adding a lot of detail and I think that's OK on the front end as the patients do react differently to the tx but side effects are pretty darn common to most. There shouldn't however be any feelings of "flying by the seat of the pants" or an office that is unorganized. He should have a regular appointment ( maybe they're trying to get that squared away ) and the full attention of his RO whenever he needs him. Don't either of you hesitate to speak up! There's no question you can ask that folks can't answer here. Best of luck to him and you.