First off I assume you are talking about testing positive for HPV oral cancer, probably squamous cell carcinoma (SCC).

A few out the 100+ strains of the HPV virus are linked to SCC, most notably 16 and 18. HPV+ SCC is currently treated just like HPV- SCC which could involve surgery, chemo (platinum based such as Cis or Carboplatin or biologically based such as Erbitux (Cetuximab)), and radiation or a combination of all three options.

If he has tested positive for HPV then there is no second opinion needed on whether or not it's HPV related but if you question how they propose to treat him, then multiple opinions may be warranted.

Has he been Staged yet?

How old?

Where is his Primary?

Does he have nodal involvement?

David

Age 58 at Dx, HPV16+ SCC, Stage IV BOT+2 nodes, non smoker, casual drinker, exercise nut, Cisplatin x 3 & concurrent IMRT x 35,(70 Gy), no surgery, no Peg, Tx at Moffitt over Aug 06. Jun 07, back to riding my bike 100 miles a wk. Now doing 12 Spin classes and 60 outdoor miles per wk. Nov 13 completed Hilly Century ride for Cancer, 104 miles, 1st Place in my age group. Apr 2014 & 15, Spun for 9 straight hrs to raise $$ for YMCA's Livestrong Program. Certified Spin Instructor Jun 2014.