Hi there! My husband got super constipated after his first Erbitux, but nothing more than that. He's had 5 now, and his skin is a wreck! That is really his only big complaint. It took about 2 full weeks for the rash to show up. Head and Shoulders helps him the most, I think more than the antibiotics or cream they gave him. He doesn't seem to get so constipated each week, either. Really was bad that first week. If she is prone to headaches, this is just something to be aware of - they have a new anti-nausea patch, with the drug Kytrol in it. They gave it to my husband and the headaches that came with that were really bad. It seems to be fairly new, but I just wanted to give you a heads up in case they offer it. Make sure they know she is throwing up, since they can give her Emend or something for that.