Sue, I had Methotrexate for 4 weekly treatments in September. The easy part for me was that it was an injection and only took a few minutes rather than Cisplatin which took hours. I did have side effects after week 3. Mouth sores, fatigue,and pluersy, no vomiting and no nausea though. My reaction was considered unusual and I was taken off of it. Wikipedia has a bit to say about it and worth reading it and the links. I want to say that it is a testimony to the Strength and Love, Neil and You Share. Remarkable. Most people refuse the 2nd treatment. Can you imagine? You both have been through so many. Keep on, Keep on, It's an inspiration to everyone! Tom

SCC Tonsil Rt T3 N2b M0 side DX Jan 04 Tx 36 Rad 3 cisplatin Tx ending May 04. partial neck dissection july 04..... July 15,08 mets to liver Age 57...Did Methotrexate Sept 08. Now on a trial drug Panitumumab, Feb4,09 treatments stopped. going to Tibetan Medicine.