Thank you all- I will pass this on and I am going to attend a consultation with my sis at Dana Farber on the 10th - so will ask all of this at that time. I only wish she had been more assertive in getting this 2nd opinion sooner (prior to her beginning her treatments), however what's done is done and I will be with her on the 10th-we;ll take it from there- funny I feel like the "big sister" now!