The way that the liver mets present themselves is a sense of hardness just below the breast bone. I thought it was my gallbladder or spleen as I thought the liver was much lower. It is right underneath the diaphram. It is a good idea to check for hardness(no give)along the breastbone and along the lower ribs. The Doctor at Sloan mentioned that they see thyroid and kidney problems even 5 or 6 years out from the original disease causing fatigue, depression. You should get these checked every year with a blood test. I also should mention I am in no pain. The only time I feel sick is when I am in Treatment. There is a balance here.Considering that there is 10-15% patient response rate (meaning a reduction of 50% of the tumor)( personally I'd be happy with stabilization and no increase) but it only happens for short period of time 2,3 maybe 6 months. the cells mutate and become resistant to the chemo and you switch. A person can function with just a very small amount of liver (5%). This is the path I am on, I am a grown up adult and I can accept it. I don't like it, but I accept it and will try to pass on as much information as possible. I go for reimaging on Oct 15. We go from there... Your Friend, Tom Roussell