Thank God for those negative biopsies. I cheered when I read that. The doc recommending chemo, though, sounds like he is really convinced that last spot is cancer--to recommend chemo without even a biopsy!

Though I guess the argument can be made that that is the best and most aggressive treatment to have and you certainly are at the best place to get a reliable opinion. Perhaps you could ask a little more about the risks would be of surgery to verify it is cancer before the chemo--maybe that would at least help you understand the recommendation.

I'll be honest here. I think if I were in your shoes, having already had one recurrence, and a doc at Johns Hopkins was saying to get chemo because the surgery would have too many other risks, I would probably (reluctantly) follow the doctor's recommendation. But that's my bias in things--I'd rather do an overly aggressive option (as long as it was recommended by a real expert) than take a chance of having to wonder later if I should have. It's a tough decision, though.

This probably isn't of much help to you, I wish I could help more.

Nelie