I, too, am amazed at the plethora of pain medications offered today. It seems to be a trial and error thing. Since we can only speak from personal experience here, I will say that the fentanyl patch sent John into outer space[literally]. We had to get him off that within a week of when it was prescribed. He has only been able to tolerate Hydrocodone. Different strokes for different folks is the rule, I think. Many of us cannot tolerate certain drugs and the question is "What can we tolerate?" Trial and error is the name of the game.