It would seem appropriate to remove the one node for biopsy, or at bare minimum do a multiple puncture fine needle biopsy. These are both minimal procedures and for little discomfort provide much information EARLY. However, the after effects of radiation can be many, and there are cases of node inflamation as a result of the healing process. Negative nodes on one side is no predictive factor that something on the other is not malignant. Bilateral cerivcal node involvement is not uncommon, and I am one patient who did have it. It is too soon after his radiation for him to be pain free, burning discomfort or otherwise. I was on heavy duty pain meds for more than 6 months after the end of my radiation.